Doubly uniparental inheritance (DUI) of mitochondrial DNA (mtDNA) represents a rare and intriguing deviation from the standard model of strictly maternal inheritance. In bivalves, DUI manifests as the ...

Transferring the nuclear genome from one egg into the cytoplasm of a donor egg is a strategy to enable women carrying mutations in their mitochondrial DNA to have healthy babies. A new study uses ...

In most eukaryotes, the inheritance of mitochondrion and its DNA (mtDNA) is strictly maternal, despite the fact that a spermatozoon can inject up to 100 functional mitochondria into the oocyte during ...

Mitochondria are often called the powerhouse of the cell, and these organelles are well-known for their energy-generating abilities. They are also special among organelles because they carry a tiny ...

Researchers from Karolinska Institutet have discovered how mammalian cells prevent the gradual buildup of harmful mutations in mitochondrial DNA, the small but vital genome that powers every cell. The ...

Researchers at the Max Delbrück Center and the University of Oxford have found that a cellular housekeeping function called autophagy—by which cell components are broken down and recycled—plays a ...