TSP-1 reduced C3 and C5 cleavage and formation of the membrane attack complex, attenuating complement-mediated injury in AAV models. Complement activation is a relevant driver in the pathomechanisms ...
The complement system, a key component of innate immunity, is a first-line defender against foreign pathogens such as HIV-1. On the other hand, complement activation also enhances HIV-1 infectivity.
These findings suggest complement protein levels may be an important biomarker for type 1 diabetes. Disruption of the complement system appears to precede the onset of islet autoimmunity (IA), making ...